Langerin (CD207) Rabbit Polyclonal Antibody

CAT#: TA349377

Rabbit Polyclonal Anti-CD207 Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: Mouse skin tissue lysate Primary antibody: TA349377 (CD207 Antibody) at dilution 1/1300 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 1 minute

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA349377 (CD207 Antibody) at dilution 1/240 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA349377 (CD207 Antibody) at dilution 1/240, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse skin tissue lysate
  IHC: 250-500
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human CD207
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 37 kDa
• Gene Name: CD207 molecule
• Database Link:
  NP_056532
  Entrez Gene 50489 Human
  UniProt ID Q9UJ71
• Background: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.
• Synonyms: CLEC4K

Reference Data

• Protein Families: Druggable Genome, Transmembrane