CTHRC1 Rabbit Polyclonal Antibody

CAT#: TA349144

Rabbit Polyclonal Anti-CTHRC1 Antibody

Product Images

Western blot analysis of CTHRC1 in rat small intestine tissue lysate with CTHRC1 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of CTHRC1 in human small intestine tissue with CTHRC1 antibody at 5 ug/mL.

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  Immunofluorescence of CTHRC1 in human small intestine tissue with CTHRC1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CTHRC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CTHRC1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: CTHRC1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 27 kDa; Observed: 27 kDa
• Gene Name: collagen triple helix repeat containing 1
• Database Link:
  NP_612464
  Entrez Gene 68588 MouseEntrez Gene 282836 RatEntrez Gene 115908 Human
  UniProt ID Q96CG8
• Background: The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration (1). CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells (2). CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer (3). Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma (4).
• Synonyms: collagen triple helix repeat containing 1

Reference Data

• Protein Families: Secreted Protein