Helicase SKI2W (SKIV2L) Rabbit Polyclonal Antibody

CAT#: TA349111

Rabbit Polyclonal Anti-GPRASP1 Antibody

Product Images

Western blot analysis of GPRASP1 in A-20 cell lysate with GPRASP1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of GPRASP1 in human breast carcinoma tissue with GPRASP12 antibody at 5 ug/mL.

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  Immunofluorescence of GPRASP1 in human breast carcinoma tissue with GPRASP1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GPRASP1 antibody was raised against a 15 amino acid peptide near the amino terminus of human GPRASP1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: GPRASP1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 153 kDa; Observed: 150 kDa
• Gene Name: Ski2 like RNA helicase
• Database Link:
  NP_008860
  Entrez Gene 6499 Human
  UniProt ID Q15477
• Background: The G protein-coupled receptor associated sorting protein 1 (GPRASP1) is a member of the GPRASP family and is thought to modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors (1,2). GPRASP1 interacts with receptors such as the D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CNR1) and targets these proteins for degradation in lysosomes (2). Recently, it has been shown that increased GPRASP1 levels may act as a potential biomarker for breast cancer (3).
• Synonyms: RUBICON; SCAR15