alpha Synuclein (SNCA) Rabbit Polyclonal Antibody

CAT#: TA349077

Rabbit Polyclonal Anti-SNCA Antibody

Product Images

Western blot analysis of SNCA in mouse cerebellum tissue lysate with SNCA antibody at 1 ug/mL.

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  Immunohistochemistry of SNCA in rat brain tissue with SNCA antibody at 5 ug/mL.

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  Immunofluorescence of SNCA in rat brain tissue with SNCA antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SNCA antibody was raised against a 19 amino acid peptide near the carboxy terminus of human SNCA.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SNCA antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 12 kDa; Observed: 16 kDa
• Gene Name: synuclein alpha
• Database Link:
  NP_000336
  Entrez Gene 6622 Human
  UniProt ID P37840
• Background: Alpha-Synuclein (SNCA) is a hallmark of Alzheimer?? disease (1,2). It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2). SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3). Defects in SNCA are associated with familial Parkinson?? disease (4,5).
• Synonyms: BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16; RTPS2; SNF2; SNF2L4; SNF2LB; SWI2