Presenilin 2 (PSEN2) Mouse Monoclonal Antibody [Clone ID: 198C679.2.]

CAT#: TA336445

Mouse Monoclonal Presenilin-2 Antibody (198C679.2.)

Specifications

Product Data

• Clone Name: 198C679.2.
• Applications: WB
• Recommended Dilution: WB: 1:250-1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Immunogen: This antibody was generated by immunizing mice with a synthetic peptide of human Presenilin-2 (PS-2).
• Formulation: Preservative: 0.1% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: presenilin 2
• Database Link:
  NP_036618
  Entrez Gene 5664 Human
  UniProt ID P49810
• Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
• Synonyms: AD3L; AD4; CMD1V; PS2; STM2

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease, Notch signaling pathway