Fos B (FOSB) Mouse Monoclonal Antibody [Clone ID: 83B1138]

CAT#: TA336391

Mouse Monoclonal FosB/G0S3 Antibody (83B1138)

Product Images

Western Blot: FosB/G0S3 Antibody (83B1138) TA336391 - Analysis of FosB in HeLa cell lysate where bands are observed at ~38 kDa representing FosB and at ~35 kDa representing delta FosB.

Specifications

Product Data

• Clone Name: 83B1138
• Applications: WB
• Recommended Dilution: Western Blot: 2 ug/mL
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: This antibody was generated by immunizing mice with a synthetic peptide corresponding to amino acids 2-15 of human FosB.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: FosB proto-oncogene, AP-1 transcription factor subunit
• Database Link:
  NP_006723
  Entrez Gene 2354 Human
  UniProt ID P53539
• Background: The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a 62 kDa nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo and heterodimers, which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine FosB encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and FosB include Fra-1 and Fra-2 genes.
• Synonyms: AP-1; G0S3; GOS3; GOSB

Reference Data

• Protein Families: Druggable Genome, Transcription Factors