ITGB3BP Rabbit Polyclonal Antibody

CAT#: TA332949

Rabbit anti-ITGB3BP Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using ITGB3BP antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human ITGB3BP
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 177
• Gene Name: integrin subunit beta 3 binding protein
• Database Link:
  NP_055103
  Entrez Gene 67733 MouseEntrez Gene 362548 RatEntrez Gene 23421 Human
  UniProt ID Q13352
• Background: This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
• Synonyms: CENP-R; CENPR; HSU37139; NRIF3; TAP20

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency, Transcription Factors