HNMT Rabbit Polyclonal Antibody

CAT#: TA332537

Rabbit anti-HNMT Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using HNMT antibody.

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  Immunofluorescence analysis of U2OS cell using HNMT antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, IP, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human HNMT
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 292
• Gene Name: histamine N-methyltransferase
• Database Link:
  NP_008826
  Entrez Gene 140483 MouseEntrez Gene 3176 Human
  UniProt ID P50135
• Background: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
• Synonyms: HMT; HNMT-S1; HNMT-S2; MRT51

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Histidine metabolism