CD45 (PTPRC) Mouse Monoclonal Antibody [Clone ID: 2B11 & PD7/26]

CAT#: TA327641

Mouse Monoclonal PTPRC (CD45) Antibody

Product Images

Immunohistochemistry staining of Paraffin Tonsil tissue by CD45 antibody (dilution: 1:100 - 1:500; visualization of staining: Membranous)

Specifications

Product Data

• Clone Name: 2B11 & PD7/26
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protein tyrosine phosphatase, receptor type C
• Database Link:
  NP_002829
  Entrez Gene 5788 Human
  UniProt ID P08575
• Synonyms: B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
• Note: Anti-CD45 (Anti-Leukocyte Common Antigen) is routinely used to aid the differential diagnosis of undifferentiated neoplasms, whenever malignant lymphoma is suspected by the morphological or clinical data. It is a highly specific antibody, therefore a positive result is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Phosphatase, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway