Cd19 Mouse Monoclonal Antibody [Clone ID: MRQ-36]

CAT#: TA327622

Mouse Monoclonal CD19 Antibody

Product Images

Immunohistochemistry staining of Paraffin Tonsil tissue by CD19 antibody (dilution: 1:25 - 1:100; visualization of staining: Membranous)

Specifications

Product Data

• Clone Name: MRQ-36
• Applications: IHC
• Recommended Dilution: IHC: 1:25 - 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD19 antigen
• Database Link:
  NP_033974
  Entrez Gene 930 Human
  UniProt ID P25918
• Synonyms: B4; Leu-12; MGC12802
• Note: CD19 is present in both benign and malignant B-cells and has long been considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the interfollicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, CD19 is also expressed in immature B-cells. Recently, Masir et al. have described the expression of CD19 in normal lymphoid tissue and its loss in B-cell neoplasms.Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms.