ZFYVE21 Rabbit Polyclonal Antibody

CAT#: TA326630

Rabbit Polyclonal ZF21 Antibody

Product Images

Western blot analysis of ZF21 in 3T3 cell tissue lysate with ZF21 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

• 

  Immunofluorescence of ZF21 in human kidney tissue with ZF21 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ZF21 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human ZF21.
• Formulation: ZF21 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: ZF21 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: zinc finger FYVE-type containing 21
• Database Link:
  NP_001185882
  Entrez Gene 79038 Human
  UniProt ID Q9BQ24
• Background: ZF21 Antibody: ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.
• Synonyms: HCVP7TP1; ZF21