Abcc9 Mouse Monoclonal Antibody [Clone ID: S319A-14]

CAT#: TA326461

Mouse Monoclonal Anti-SUR2A Antibody

Specifications

Product Data

• Clone Name: S319A-14
• Reactivities: Rat, Mouse
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 1505-1546 (SSIVDAGLVLVFSEGILVECDTGPNLLQH KNGLFSTLVMTNK, cytoplasmic C-terminus) of mouse SUR2A
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
• Database Link:
  NP_001038185
  Entrez Gene 25560 RatEntrez Gene 20928 Mouse
  UniProt ID P70170
• Background: Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inwardrectifier potassium ion channels Kir6.x (6.1 and 6.2) . The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel.The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell .
• Synonyms: ABC37; CMD1O; FLJ36852; SUR2
• Note: Detects ~120kDa. Does not cross-react with SUR2B