Tyrosinase (TYR) Rabbit Polyclonal Antibody

CAT#: TA323680

Anti-TYR Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 50 μg Lane 1-3: A375 cells Hela cells Jurkat cells Primary antibody: TA323680 (TYR Antibody) at dilution 1/400 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 3 minutes

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA323680 (TYR Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA323680 (TYR Antibody) at dilution 1/30, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA323680 (TYR Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA323680 (TYR Antibody) at dilution 1/30, treated with fusion protein. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: A375, Hela and Jurkat cells
  IHC: 25-100
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 19-319 amino acids of human tyrosinase
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 60 kDa
• Gene Name: tyrosinase
• Database Link:
  NP_000363
  Entrez Gene 22173 MouseEntrez Gene 7299 Human
  UniProt ID P14679
• Background: The enzyme encoded by this gene catalyzes the first 2 steps; and at least 1 subsequent step; in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities; and requires copper for function. Mutations in this gene result in oculocutaneous albinism; and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
• Synonyms: ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Melanogenesis, Metabolic pathways, Riboflavin metabolism, Tyrosine metabolism