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Amyloid Precursor Protein (APP) Rabbit Polyclonal Antibody
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USD 200.00
USD 867.00
USD 436.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommended Dilution | WB: 1000-5000 WB positive control: Raji and Jurkat cell lysates IHC: 25-50 Positive control: Human prostate cancer Predicted cell location: Nucleus |
| Reactivities | Human, Mouse, Rat |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 44-62 amino acids of Human Amyloid protein precursor |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Predicted Protein Size | 87 kDa |
| Gene Name | amyloid beta precursor protein |
| Database Link | |
| Background | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation; while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. |
| Synonyms | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2 |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Alzheimer's disease |
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