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p95 NBS1 (NBN) Rabbit Polyclonal Antibody
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Specifications
| Product Data | |
| Applications | IHC |
| Recommended Dilution | IHC: 25-100 Positive control: Human breast cancer Predicted cell location: Cytoplasm |
| Reactivities | Human, Mouse, Rat |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 729-743 amino acids of human nibrin |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Gene Name | nibrin |
| Database Link | |
| Background | Mutations in this gene are associated with Nijmegen breakage syndrome; an autosomal recessive chromosomal instability syndrome characterized by microcephaly; growth retardation; immunodeficiency; and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. |
| Synonyms | AT-V1; AT-V2; ATV; NBS; NBS1; P95 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Homologous recombination |
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