ADO Rabbit Polyclonal Antibody

CAT#: TA322128

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Anti-ADO Rabbit Polyclonal Antibody



USD 345.00


Availability*
In Stock

Size
    • 100 ul


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Specifications

Product Data
Applications WB
Recommended Dilution ELISA: 1:1000-10000, WB: 1:1000-5000
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 161-174 amino acids of Human 2-aminoethanethiol (cysteamine) dioxygenase
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration 2.4mg/ml
Purification Antigen affinity purification
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 30 kDa
Gene Name 2-aminoethanethiol (cysteamine) dioxygenase
Background Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine; whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. Mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar results were found with human ADO. When endogenous expression of ADO was reduced by RNA-mediated interference; hypotaurine production decreased. The demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity.
Synonyms C10orf22
Reference Data
Protein Pathways Metabolic pathways, Taurine and hypotaurine metabolism
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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