Agrin (AGRN) Rabbit Polyclonal Antibody

CAT#: TA321970

Anti-AGRN Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA321970 (AGRN Antibody) at dilution 1/50 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA321970 (AGRN Antibody) at dilution 1/50, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 74-84 amino acids of human agrin
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: agrin
• Database Link:
  NP_940978
  Entrez Gene 375790 Human
  UniProt ID O00468
• Background: This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ); as identified in mouse knock-out studies. The encoded protein contains several laminin G; Kazal type serine protease inhibitor; and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles; a mutation in this gene was found.
• Synonyms: CMS8; CMSPPD

Reference Data

• Protein Pathways: ECM-receptor interaction