ADAM17 Rabbit Polyclonal Antibody

CAT#: TA321563

Anti-ADAM17 Rabbit Polyclonal Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane 1-5: Jurkat Raji Hela K562 293T cell lysates Primary antibody: TA321563 (ADAM17 Antibody) at dilution 1/550 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 90 seconds

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  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA321563 (ADAM17 Antibody) at dilution 1/50 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA321563 (ADAM17 Antibody) at dilution 1/50, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA321563 (ADAM17 Antibody) at dilution 1/50 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA321563 (ADAM17 Antibody) at dilution 1/50, treated with fusion protein. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Jurkat, Raji, Hela, K562, 293T cell lysates
  IHC: 50-200
  Positive control: Human breast cancer
  Predicted cell location: Cytoplasm and Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ADAM metallopeptidase domain 17
• Database Link:
  NP_003174
  Entrez Gene 11491 MouseEntrez Gene 57027 RatEntrez Gene 6868 Human
  UniProt ID P78536
• Background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.?
• Synonyms: ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway