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Estrogen Receptor 1 (ESR1) Rabbit Polyclonal Antibody
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USD 665.00
USD 200.00
USD 867.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommended Dilution | IHC: 100-300 Positive control: Human brain Predicted cell location: Cytoplasm, Nucleus |
| Reactivities | Human, Mouse, Rat |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 247-261 amino acids of Human estrogen receptor 1 |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Gene Name | estrogen receptor 1 |
| Database Link | |
| Background | This gene encodes an estrogen receptor; a ligand-activated transcription factor composed of several domains important for hormone binding; DNA binding; and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function; but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer; endometrial cancer; and osteoporosis. Alternative splicing results in several transcript variants; which differ in their 5' UTRs and use different promoters. |
| Synonyms | ER; Era; ESR; ESRA; ESTRR; NR3A1 |
| Reference Data | |
| Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
Documents
| Product Manuals |
| FAQs |
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