SELK (SELENOK) Rabbit Polyclonal Antibody

CAT#: TA319992

Rabbit Polyclonal SELK Antibody

Product Images

Western blot analysis of SELK in A20 cell lysate with SELK antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of SELK in human heart tissue with SELK antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SELK antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SELK.
• Formulation: SELK Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: SELK Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 10 kDa
• Gene Name: selenoprotein K
• Database Link:
  NP_067060
  Entrez Gene 80795 MouseEntrez Gene 290549 RatEntrez Gene 58515 Human
  UniProt ID Q9Y6D0
• Background: SELK Antibody: SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited
• Synonyms: HSPC030; HSPC297

Reference Data

• Protein Families: Transmembrane