GPR44 (PTGDR2) Rabbit Polyclonal Antibody

CAT#: TA319833

Rabbit Polyclonal PTGDR2 Antibody

Product Images

Western blot analysis of PTGDR2 in small intestine tissue lysate with PTGDR2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunofluorescence of PTGDR2 in human small intestine tissue with PTGDR2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Rabbit polyclonal PTGDR2 antibody was raised against a 19 amino acid peptide near the center of human PTGDR2.
• Formulation: PTGDR2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: PTGDR2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 43 kDa
• Gene Name: prostaglandin D2 receptor 2
• Database Link:
  NP_004769
  Entrez Gene 14764 MouseEntrez Gene 11251 Human
  UniProt ID Q9Y5Y4
• Background: PTGDR2 Antibody: The prostaglandin D2 receptor 2 (PTGDR2), also known as CRTH2, is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, PTGDR2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the PTGDR2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that PTGDR2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.
• Synonyms: CD294; CRTH2; DL1R; DP2; GPR44

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane