Apc6 (CDC16) Rabbit Polyclonal Antibody

CAT#: TA319762

Rabbit Polyclonal APC6 Antibody

Product Images

Western blot analysis of APC6 in human liver tissue lysate with APC6 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of APC6 in human liver tissue with APC6 antibody at 5 ug/mL.

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  Immunofluorescence of APC6 in human liver tissue with APC6 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: APC6 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human APC6.
• Formulation: APC6 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: APC6 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cell division cycle 16
• Database Link:
  NP_003894
  Entrez Gene 8881 Human
  UniProt ID Q13042
• Background: APC6 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC6 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC6, it has been shown to interact with and is stabilized by CDC26 through an intermolecular TPR mimic composed of one helix from each protein.
• Synonyms: ANAPC6; APC6; CDC16Hs; CUT9