KAL1 (ANOS1) Rabbit Polyclonal Antibody

CAT#: TA319670

Rabbit Polyclonal Anosmin Antibody

Product Images

Western blot analysis of Anosmin in MCF7 cell lysate with Anosmin antibody at 1 ug/mL.

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  Immunofluorescence of Anosmin in MCF7 cells with Anosmin antibody at 20 ug/mL.

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  Immunocytochemistry of Anosmin in MCF7 cells with Anosmin antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Anosmin antibody was raised against an 18 amino acid synthetic peptide near the center of human Anosmin.
• Formulation: Anosmin Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Anosmin Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: anosmin 1
• Database Link:
  NP_000207
  Entrez Gene 3730 Human
  UniProt ID P23352
• Background: Anosmin Antibody: Mutations in Anosmin-1, an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.
• Synonyms: ADMLX; HH1; HHA; KAL; KAL1; KALIG-1; KMS; WFDC19