Bestrophin (BEST1) Mouse Monoclonal Antibody [Clone ID: E6-6]
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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
USD 200.00
Other products for "Bestrophin"
Specifications
Product Data | |
Clone Name | E6-6 |
Applications | ICC/IF, IHC, IP, WB |
Recommended Dilution | Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry, Proximity Ligation Assay, Immunoprecipitation, Knockout Validated, Western Blot: 1:1000, Immunohistochemistry-Frozen, Dual RNAscope ISH-IHC |
Reactivities | Human, Porcine, Primate |
Host | Mouse |
Isotype | IgG1, kappa |
Clonality | Monoclonal |
Immunogen | Synthetic peptide conjugated to KLH [KDHMDPYWALENRDEAHS]. |
Formulation | 0.1% Sodium Azide |
Purification | Ascites |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 68 kDa |
Gene Name | bestrophin 1 |
Database Link | |
Background | Best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). It is inherited and has an early onset. Bestrophin is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells. |
Synonyms | ARB; BEST; BMD; RP50; TU15B; VMD2 |
Reference Data | |
Protein Families | Druggable Genome, Ion Channels: Other, Transmembrane |
Documents
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