Protein C (PROC) Rabbit Polyclonal Antibody

CAT#: TA308939

Rabbit polyclonal antibody to Protein C (protein C (inactivator of coagulation factors Va and VIIIa))

Product Images

Sample (30 ug of whole cell lysate). A: Molt-4. 10% SDS PAGE. TA308939 diluted at 1:3000

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human (Predicted: Dog)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 145 and 461 of Protein C (Uniprot ID#P04070)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52 kDa
• Gene Name: protein C, inactivator of coagulation factors Va and VIIIa
• Database Link:
  NP_000303
  Entrez Gene 476104 DogEntrez Gene 5624 Human
  UniProt ID P04070
• Background: The PROC gene encodes protein C (EC 3.4.21.69), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, 'activated protein C' (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930; MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5; MIM 612309) and VIII (F8; see MIM 306700). Protein S (PROS1; MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C. [supplied by OMIM]
• Synonyms: APC; PC; PROC1; THPH3; THPH4
• Note: Seq homology of immunogen across species: Dog (82%)

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Complement and coagulation cascades