Carbonic Anhydrase XI (CA11) Rabbit Polyclonal Antibody

CAT#: TA308859

Rabbit polyclonal antibody to CA11 (carbonic anhydrase XI)

Product Images

Sample (30 ug of whole cell lysate). A: A431. 10% SDS PAGE. TA308859 diluted at 1:500.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human (Predicted: Bovine)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 311 of CA11 (Uniprot ID#O75493)
• Formulation: 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 36 kDa
• Gene Name: carbonic anhydrase 11
• Database Link:
  NP_001208
  Entrez Gene 770 Human
  UniProt ID O75493
• Background: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq]
• Synonyms: CARPX1
• Note: Seq homology of immunogen across species: Bovine (97%)

Reference Data

• Protein Families: Druggable Genome, Secreted Protein