ASPA Rabbit Polyclonal Antibody

CAT#: TA308661

Rabbit Polyclonal antibody to Aspartoacylase (aspartoacylase (Canavan disease))

Product Images

Sample (30 ug of whole cell lysate). A: Molt-4. B: Raji. 10% SDS PAGE. TA308661 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using Aspartoacylase (TA308661) antibody at 1:100 dilution.

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Aspartoacylase (TA308661) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human (Predicted: Mouse, Pig, Bovine)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 39 and 300 of Aspartoacylase (Uniprot ID#P45381)
• Formulation: 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 36 kDa
• Gene Name: aspartoacylase
• Database Link:
  NP_001121557
  Entrez Gene 11484 MouseEntrez Gene 443 Human
  UniProt ID P45381
• Background: This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
• Synonyms: ACY2; ASP
• Note: Seq homology of immunogen across species: Mouse (87%), Pig (95%), Bovine (93%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alanine, aspartate and glutamate metabolism, Histidine metabolism