Girdin (CCDC88A) Rabbit Polyclonal Antibody

CAT#: TA306896

Rabbit Polyclonal Girdin Antibody

Product Images

Western blot analysis of Girdin in rat brain tissue lysate with Girdin antibody at (A) 1 and (B) 2 ug/ml.

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  Immunofluorescence of Girdin in cells with Girdin antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Girdin antibody was raised against a 16 amino acid peptide from near the carboxy terminus human Girdin.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: coiled-coil domain containing 88A
• Database Link:
  NP_060554
  Entrez Gene 55704 Human
  UniProt ID Q3V6T2
• Background: Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
• Synonyms: APE; GIRDIN; GIV; GRDN; HkRP1; KIAA1212; PEHO