KCTD15 Rabbit Polyclonal Antibody
Rabbit Polyclonal KCTD15 Antibody
Product Datasheet for 'TA306747'
|Applications||IF, IHC, WB|
|Recommend Dilution||WB: 0.5 - 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL|
|Reactivity||Human, Mouse, Rat|
|Immunogen||KCTD15 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human KCTD15.|
|Formulation||PBS containing 0.02% sodium azide.|
|Purification||Affinity chromatography purified via peptide column|
|Gene Name||potassium channel tetramerization domain containing 15|
|Background||Childhood and adult obesity in the United States and to a lesser extent the rest of the world has increased dramatically over the past decade. Both environmental and genetic factors are involved in the onset and progression of weight gain. Recently, the potassium channel KCTD15 was identified as a genetic loci associated with higher than normal body mass index (BMI) in humans along with genes such as GNPDA2, MTCH2, FTO, and TMEM18. Further studies on single nucleotide polymorphisms (SNPs) in non-diabetic and diabetic patients showed that FTO was most strongly associated with obesity while MTCH2 and GNPDA2 were still significantly associated with higher than normal BMI levels. At least two isoforms of KCTD15 are known to exist.|
|Protein Families||Ion Channels: Other|
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