TNPO3 Rabbit Polyclonal Antibody

CAT#: TA306573

Rabbit Polyclonal TNPO3 Antibody

Product Images

Western blot analysis of TNPO3 in rat liver tissue lysate with TNPO3 antibody at (A) 1 and (B) 2ug/ml.

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  Western blot analysis of TNPO3 expression in Jurkat cell lysate with TNPO3 antibody at (A) 1 and (B) 2ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TNPO3 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human TNPO3. The immunogen is located within amino acids 220 - 270 of TNPO3.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transportin 3
• Database Link:
  NP_036602
  Entrez Gene 296954 RatEntrez Gene 320938 MouseEntrez Gene 23534 Human
  UniProt ID Q9Y5L0
• Background: TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
• Synonyms: IPO12; LGMD1F; MTR10A; TRN-SR; TRN-SR2; TRNSR

Reference Data

• Protein Families: Druggable Genome