TEM4 (ARHGEF17) Rabbit Polyclonal Antibody

CAT#: TA306487

Rabbit Polyclonal TEM4 Antibody

Product Images

Western blot analysis of TEM4 in Jurkat Cell lysate with TEM4 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of TEM4 in human spleen tissue with TEM4 antibody at 2.5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TEM4 antibody was raised against a 18 amino acid peptide near the center of human TEM4.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Rho guanine nucleotide exchange factor 17
• Database Link:
  NP_055601
  Entrez Gene 9828 Human
  UniProt ID Q96PE2
• Background: Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
• Synonyms: p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4

Reference Data

• Protein Families: Druggable Genome