TDP43 (TARDBP) Rabbit Polyclonal Antibody

CAT#: TA306453

Rabbit Polyclonal TDP43 Antibody

Product Images

Western blot analysis of TDP43 in HeLa cell lysate with TDP43 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.

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  Immunocytochemistry of TDP43 in HeLa cells with TDP43 antibody at 5 ug/mL.

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  Immunofluorescence of TDP43 in Hela cells with TDP43 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TDP43 antibody was raised against a 15 amino acid peptide from near the amino terminus of human TDP43.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TAR DNA binding protein
• Database Link:
  ABO32290
  Entrez Gene 23435 Human
  UniProt ID Q13148
• Background: TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3’ splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. At least two isoforms are known to exist for this protein; this TDP43 antibody will recognize both isoforms.
• Synonyms: ALS10; TDP-43