NKIRAS2 Rabbit Polyclonal Antibody

CAT#: TA306085

Rabbit Polyclonal KappaB ras2 Antibody

Product Images

Western blot analysis of KappaB ras2 in RAW264.7 cell lysate with KappaB ras1 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KappaB ras2 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human KappaB ras2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NFKB inhibitor interacting Ras like 2
• Database Link:
  NP_060065
  Entrez Gene 28511 Human
  UniProt ID Q9NYR9
• Background: KappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody is specific for kappaB-ras2 and has no cross-reactivity to kappaB-ras1.
• Synonyms: kappaB-Ras2; KBRAS2