BubR1 (BUB1B) Mouse Monoclonal Antibody [Clone ID: 8G1]
USD 436.00
USD 200.00
USD 867.00
Specifications
Product Data | |
Clone Name | 8G1 |
Applications | CyTOF-ready, FC, ICC/IF, IP, WB |
Recommended Dilution | Flow Cytometry: 1 ug per million cells, Immunoprecipitation: 1:10-1:500, Western Blot: 1:2000-1:5000, Immunocytochemistry/ Immunofluorescence: 1:100, CyTOF-ready |
Reactivities | Human, Mouse |
Host | Mouse |
Isotype | IgG1, kappa |
Clonality | Monoclonal |
Immunogen | A portion of hBUBR1 tagged at the N-terminus with pMAL (residues 1-350 of human BUBR1). |
Formulation | PBS with 0.1% Sodium Azide |
Purification | Protein G purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 119.4 kDa |
Gene Name | BUB1 mitotic checkpoint serine/threonine kinase B |
Database Link | |
Background | Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1. |
Synonyms | Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase, Stem cell - Pluripotency |
Protein Pathways | Cell cycle |
Documents
Product Manuals |
FAQs |
SDS |
{0} Product Review(s)
Be the first one to submit a review