APE1(APEX1) Rabbit Polyclonal Antibody

CAT#: TA301441

Rabbit Polyclonal Antibody against APE1

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 Product Datasheet for 'TA301441'

USD 474.00


Availability*
In Stock

Size
    • 100 ul

Product images

Specifications

Product Data
Applications WB, IHC, IF
Recommend Dilution WB: 1: 1000
Reactivity human, mouse, rat
Host Rabbit
Clonality Polyclonal
Immunogen Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein.
Isotype IgG
Formulation Tris-glycine, 150mM NaCl and 0.05% sodium azide
Reconstitution Method Reconstitute with PBS (pH7.3). To use this carrier-free antibody for conjugation experiment, we strongly recommend you to perform another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Affinity purified
Gene Name apurinic/apyrimidinic endodeoxyribonuclease 1
Background The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1a as well as other transcription factors. Recently, APE has also been shown to control p53 activity through redox alteration. APE is also linked to apoptosis, associated with thioredoxin, and altered levels of APE have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.
Synonyms APE|APE1|APEN|APEX|APX|HAP1|REF1
Reference Data
Protein Families Stem cell - Pluripotency, Transcription Factors, Druggable Genome
Protein Pathways Base excision repair
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.