alpha 1 Antitrypsin (SERPINA1) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | IF, IHC |
Recommended Dilution | Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections and cell smears): 1/50-1/100 using streptavidin~biotin system or polymer system. FFPE tissue sections require antigen retriever (boiling tissue in 10 mM citrate pH 6.0 for 10-20 minutes, followed by cooling at RT for 15-20 minutes). Recommended Positive Control: Human tonsil, liver. |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Purified human ATT. |
Specificity | This antiboydy is specific for Alpha-1-Antitrypsin (AAT). Cellular Localization: Cytoplasmic staining of macrophages. |
Formulation | PBS, pH 7.4 containing 0.05% Sodium Azide as preservative and 1% BSA as stabilizer. State: Purified State: Liquid purified Ig fraction. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: One year from despatch. |
Gene Name | serpin family A member 1 |
Database Link | |
Background | Alpha-1-Antitrypsin (AAT) is a 51 kDa glycoprotein synthesized in the liver. It is a serum protease inhibitor in neutrophil elastase, collagenase and chymotrypsin. This protein is a serum trypsin inhibitor, the correct name is alpha-1-proteinase inhibitor (A1PI). Disorders of this enzyme include, deficiency, in a hereditary disorder, this causes degradation of lung tissue and causes pulmonary emphysema, it also causes chronic liver disease and hepatocarcinoma. AAT is present in normal liver cells, histocytes, monocytes and a variety of epithelial and mesenchymal tumors. Increase in serum levels of AAT is also reported in rheumatoid arthritis, bacterial infection, vasculistis and carcinomatosis. |
Synonyms | SERPINA1, AAT |
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