CD51 (ITGAV) Mouse Monoclonal Antibody [Clone ID: 13C2]
CD51 (ITGAV) mouse monoclonal antibody, clone 13C2, FITC
|Recommended Dilution||Flow Cytometry: 10 µL/10e6 cells.|
|Specificity||This antibody recognizes CD51.|
|Formulation||PBS containing 0.09% Sodium Azide as preservative.
State: Liquid purified Ig fraction.
Label: Fluorescein Isothiocyanate Isomer 1
|Storage||Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Gene Name||integrin subunit alpha V|
|Background||Integrin alpha V chain interacts with the integrin beta 3 subunit/CD61 to form the alpha-V-beta-3 heterodimer/vitronectin receptor. It is expressed on endothelial cells, some activated leukocytes, NK cells, macrophages, neutrophils, and platelets. Integrin alpha V also forms heterodimers with the integrin beta 1, beta 5, beta 6, and beta 8 subunits. Alpha-V-beta-3 is an activation dependent receptor for platelet attachment and spreading on vitronectin and other matrix components. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus By similarity. Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.
It also mediates leukocyte-endothelial cell adhesion via interaction with CD31. (Ref.1-4)
|Synonyms||Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.