CD51 (ITGAV) Mouse Monoclonal Antibody [Clone ID: 13C2]

CAT#: AM08161PU-N

CD51 (ITGAV) mouse monoclonal antibody, clone 13C2, Purified

Specifications

Product Data

• Clone Name: 13C2
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry: ≤ 1 µg/10⁶ cells (Reported in literature 7,9,10).
  Immunohistochemistry on Frozen Sections (Reported in literature 1,5).
  Immunocytochemistry (Reported in literature 3).
  Immunoprecipitation (Reported in literature 2,3,5,9).
  ELISA (Reported in literature 8).
  Purification (Reported in literature 4,5).
  Depletion (Reported in literature 7).
  Blocking (Reported in literature 3,6).
  Adhesion (Reported in literature 3).
  
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Cell suspension containing osteoclasts from osteoclastomas.
• Specificity: This antibody recognizes CD51.
• Formulation: 100 mM Borate Buffered Saline, pH 8.2.
  No preservatives or amine-containing buffer salts added.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin subunit alpha V
• Database Link:
  Entrez Gene 3685 Human
  UniProt ID P06756
• Background: Integrin alpha V chain interacts with the integrin beta 3 subunit/CD61 to form the alpha-V-beta-3 heterodimer/vitronectin receptor. It is expressed on endothelial cells, some activated leukocytes, NK cells, macrophages, neutrophils, and platelets. Integrin alpha V also forms heterodimers with the integrin beta 1, beta 5, beta 6, and beta 8 subunits. Alpha-V-beta-3 is an activation dependent receptor for platelet attachment and spreading on vitronectin and other matrix components. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus By similarity. Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.
  It also mediates leukocyte-endothelial cell adhesion via interaction with CD31. (Ref.1-4)
• Synonyms: Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha