CD51 (ITGAV) Mouse Monoclonal Antibody [Clone ID: 13C2]

CAT#: AM08161PU-N

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CD51 (ITGAV) mouse monoclonal antibody, clone 13C2, Purified



USD 246.00


Availability*
3 Days

Size
    • 100 ug


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Specifications

Product Data
Clone Name 13C2
Applications FC, IHC
Recommended Dilution Flow Cytometry: ≤ 1 µg/106 cells (Reported in literature 7,9,10).  
Immunohistochemistry on Frozen Sections (Reported in literature 1,5) 
Immunocytochemistry (Reported in literature 3).
Immunoprecipitation
(Reported in literature 2,3,5,9).
ELISA
(Reported in literature 8).
Purification
(Reported in literature 4,5).
Depletion (Reported in literature 7).
Blocking (Reported in literature 3,6).
Adhesion
(Reported in literature 3).
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Cell suspension containing osteoclasts from osteoclastomas.
Specificity This antibody recognizes CD51.
Formulation 100 mM Borate Buffered Saline, pH 8.2.
No preservatives or amine-containing buffer salts added.
State: Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Conjugation Unconjugated
Storage Store undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Gene Name integrin subunit alpha V
Background Integrin alpha V chain interacts with the integrin beta 3 subunit/CD61 to form the alpha-V-beta-3 heterodimer/vitronectin receptor. It is expressed on endothelial cells, some activated leukocytes, NK cells, macrophages, neutrophils, and platelets. Integrin alpha V also forms heterodimers with the integrin beta 1, beta 5, beta 6, and beta 8 subunits. Alpha-V-beta-3 is an activation dependent receptor for platelet attachment and spreading on vitronectin and other matrix components. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus By similarity. Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.
It also mediates leukocyte-endothelial cell adhesion via interaction with CD31. (Ref.1-4)
Synonyms Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha
Reference Data
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