Serine Palmitoyltransferase (SPTLC2) (NM_004863) Human Recombinant Protein

CAT#: TP762535

Purified recombinant protein of Human serine palmitoyltransferase, long chain base subunit 2 (SPTLC2), 50ug

Product Images

Coomassie blue staining of purified SPTLC2 protein (Cat #TP762535). The protein was produced from E.coli.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region full length of SPTLC2
• Tag: N-GST and C-HIS
• Predicted MW: 62.9 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50mM Tris, pH8.0, 8M Urea
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_004854
• Locus ID: 9517
• UniProt ID: O15270, A0A024R6H1
• Cytogenetics: 14q24.3
• Refseq Size: 8164
• Refseq ORF: 1686
• Synonyms: hLCB2a; HSN1C; LCB2; LCB2A; NSAN1C; SPT2
• Summary: This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]
• Protein Pathways: Metabolic pathways, Sphingolipid metabolism