SINHCAF (NM_001135811) Human Recombinant Protein

CAT#: TP762484

Purified recombinant protein of Human family with sequence similarity 60, member A (FAM60A), transcript variant 1, full length, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein FAM60A was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region full length of FAM60A
• Tag: N-His
• Predicted MW: 24.9 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_001129283
• Locus ID: 58516
• UniProt ID: Q9NP50
• Cytogenetics: 12p11.21
• Refseq Size: 3134
• Refseq ORF: 663
• Synonyms: C12orf14; FAM60A; L4; TERA
• Summary: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity).[UniProtKB/Swiss-Prot Function]