TRPM8 (NM_024080) Human Recombinant Protein

CAT#: TP762324

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Purified recombinant protein of Human transient receptor potential cation channel, subfamily M, member 8 (TRPM8), Met1-Pro300, with N-terminal His tag, expressed in E.coli, 50ug



  View other "TRPM8" proteins (2)

USD 205.00


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    • 50 ug


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Product Data
Description Purified recombinant protein of Human transient receptor potential cation channel, subfamily M, member 8 (TRPM8), Met1-Pro300, with N-terminal His tag, expressed in E.coli, 50ug
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding the region(Met1-Pro300) of TRPM8
Tag N-His
Predicted MW 34.3 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, pH8.0, 8M Urea
Storage Store at -80°C after receiving vials.
Stability Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_076985
Locus ID 79054
UniProt ID Q7Z2W7, W8DTH1
Cytogenetics 2q37.1
Refseq Size 5674
Refseq ORF 3312
Synonyms LTrpC-6; LTRPC6; trp-p8; TRPP8
Summary Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.[UniProtKB/Swiss-Prot Function]
Protein Families Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

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