ABCD2 (NM_005164) Human Recombinant Protein

CAT#: TP762219

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Purified recombinant protein of Human ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2), Gly418-His506, with N-terminal His-ABP tag, expressed in E.coli, 50ug



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USD 205.00


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    • 50 ug


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Product Data
Description Purified recombinant protein of Human ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2), Gly418-His506, with N-terminal His-ABP tag, expressed in E.coli, 50ug
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding the region(Gly418-His506) of ABCD2
Tag N-His ABP
Predicted MW 25.4 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, 8M Urea, pH8.0.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_005155
Locus ID 225
Refseq Size 5341
Cytogenetics 12q12
Refseq ORF 2220
Synonyms ABC39; ALDL1; ALDR; ALDRP; hALDR
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways ABC transporters

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