MDM2 (NM_002392) Human Recombinant Protein

CAT#: TP761916

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Purified recombinant protein of Human Mdm2 p53 binding protein homolog (mouse) (MDM2), transcript variant MDM2, Gln119-Leu438, with N-terminal HIS tag, expressed in E. coli, 50ug


 Product Datasheet for 'TP761916'

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USD 205.00


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    • 50 ug


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Product Data
Description Purified recombinant protein of Human Mdm2 p53 binding protein homolog (mouse) (MDM2), transcript variant MDM2, Gln119-Leu438, with N-terminal HIS tag, expressed in E. coli, 50ug
Species Human
Expression Host E. coli
Tag N-His
Predicted MW 35.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0,150 mM NaCl, 10% glycerol
Reference Data
RefSeq NP_002383
Locus ID 4193
Refseq Size 2357
Cytogenetics 12q15
Refseq ORF 1491
Synonyms ACTFS; hdm2; HDMX
Summary This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, Endocytosis, Glioma, Melanoma, p53 signaling pathway, Pathways in cancer, Prostate cancer, Ubiquitin mediated proteolysis

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MDM2 mouse monoclonal antibody, clone OTI1E6 (formerly 1E6)
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USD 360.00

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68 Mouse Clones
HUMAN PROREINS 101