PAX6 (NM_001604) Human Recombinant Protein

CAT#: TP760453

Reviews ()
Write a review

Purified recombinant protein of Human paired box 6 (PAX6), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug


 Product Datasheet for 'TP760453'

  View other "PAX6" proteins (4)

USD 205.00


Availability*
In Stock

Size
    • 50 ug


Product images

Specifications

Product Data
Description Purified recombinant protein of Human paired box 6 (PAX6), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Species Human
Expression Host E. coli
Tag N-His
Predicted MW 48 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Reference Data
RefSeq NP_001595
Locus ID 5080
Refseq Size 2781
Cytogenetics 11p13
Refseq ORF 1308
Synonyms AN; AN2; ASGD5; D11S812E; FVH1; MGDA; WAGR
Summary This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019]
Protein Families Adult stem cells, Druggable Genome, Embryonic stem cells, Transcription Factors
Protein Pathways Maturity onset diabetes of the young

Documents

Other Versions

Other products for "PAX6"
Frequently bought together (1)
Goat Polyclonal Antibody against PAX6
    • 100 ug

USD 360.00

Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
68 Mouse Clones
HUMAN PROREINS 101