Tnf Rat Recombinant Protein

CAT#: TP727603

Recombinant Rat Tumor Necrosis Factor/TNF-alpha

Specifications

Product Data

• Species: Rat
• Protein Source: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Leu80-Leu235
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
• Note: Recombinant Rat Tumor Necrosis Factor is produced by our E.coli expression system and the target gene encoding Leu80-Leu235 is expressed.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 24835
• UniProt ID: P16599
• Summary: Tumor necrosis factor alpha (TNF-alpha, TNFSF2) is the prototypic ligand of the TNF superfamily. Rat TNF-alpha consisits of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 179 aa extracellular domain (ECD). Within the ECD, rat TNF-alpha shares 94% aa sequence identity with mouse. TNF-alpha is produced by a wide variety of immune, epithelial, endothelial, and tumor cells. TNF exists as a homotrimer and interacts with SPPL2B. TNF is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. TNF is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes throught its effects on insulin resistance and fatty acid metabolism.