CD80 Rabbit Recombinant Protein

CAT#: TP727542

Recombinant Rabbit B7-1/CD80 (C-6His)

Specifications

Product Data

• Species: Rabbit
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Gly33-Gln241
• Tag: C-His
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
• Note: Recombinant Rabbit T-lymphocyte Activation Antigen CD82 is produced by our Mammalian expression system and the target gene encoding Gly33-Gln241 is expressed with a 6His tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 100009377
• Summary: Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.