Thpo Mouse Recombinant Protein
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Specifications
Product Data | |
Species | Mouse |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Ser22-Thr356
|
Tag | N-His |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS,2mM EDTA,pH7.4. |
Note | Recombinant Mouse Thrombopoietin is produced by our Mammalian expression system and the target gene encoding Ser22ÂThr356 is expressed with a 6His tag at the N-terminus. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 21832 |
UniProt ID | P40226 |
Summary | Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets.Mature mouse Tpo shares 71% and 81% aa sequence homology with human and rat Tpo, respectively. It is an 80-85 kDa protein that consists of an N-terminal domain with homology to Erythropoietin (Epo) and a C-terminal domain that contains multiple N-linked and O-linked glycosylation sites. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
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