Il4 Mouse Recombinant Protein

CAT#: TP727318

Recombinant Mouse Interleukin-4/IL-4

Specifications

Product Data

• Species: Mouse
• Protein Source: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  His23-Ser140
• Buffer: Lyophilized from a 0.2 um filtered solution of 20mM PB, 300mM NaCl, 5% Trehalose, pH 6.5.
• Note: Recombinant Mouse Interleukin-4 is produced by our E.coli expression system and the target gene encoding His23-Ser140 is expressed.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 16189
• UniProt ID: P07750
• Summary: Mouse Interleukin-4(IL-4) is a monomeric, Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α­helix structure. IL­4 exerts its effects through two receptor complexes, Participates in at least several B-cell activation processes as well as of other cell types. IL­4 is primarily expressed by Th2­biased CD4+T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4+T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL­4 plays a dominant role in the development of allergic inflammation and asthma. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.