Hgf Mouse Recombinant Protein

CAT#: TP727080

Recombinant Mouse HGF (C-6His)

Specifications

Product Data

• Species: Mouse
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Gln33-Leu728
• Tag: C-6His
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
• Note: Recombinant Mouse Hepatocyte growth factor is produced by our Mammalian expression system and the target gene encoding Gln33­Leu728 is expressed with a 6His tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 15234
• UniProt ID: Q08048
• Summary: HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases. Mouse HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha  and 30 kDa beta  chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF regulates epithelial morphogenesis by inducing cell scattering and branching tubulogenesis.  It can also alter epithelium morphology by the induction of nectin‑1 alpha  ectodomain shedding, an adhesion protein component of adherens junctions .