SLAMF7 Human Recombinant Protein

CAT#: TP726688

Recombinant Human SLAMF7 (C-mFc)

Specifications

Product Data

• Species: Human
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Ser23-Met226
• Tag: C-mFc
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
• Note: Recombinant Human SLAM Family Member 7 is produced by our Mammalian expression system and the target gene encoding Ser23-Met226 is expressed with a mFc tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 57823
• UniProt ID: Q9NQ25
• Summary: SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.